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All Journal e-Journal Pustaka Kesehatan Jurnal Kesehatan Andalas Journal of Agromedicine and Medical Sciences Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Kedokteran Andalas Jurnal Kesmas Untika Luwuk: Public Health Journal
Cholis Abrori, Cholis
Department Of Pharmacology, Faculty Of Medicine, University Of Jember, Indonesia
Health Professions Library & Information Science Medicine & Pharmacology Public Health

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Journal : Journal of Agromedicine and Medical Sciences

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Slow Release Metformin Effect in Weight Loss and Total Calorie Intake in Obese Volunteers Cholis Abrori; Lucky Tiya; Deti Rosalina
Journal of Agromedicine and Medical Sciences Vol 3 No 1 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i1.4098

Abstract

Obesity can cause serious problems that will lead to poor quality of life, increased morbidity and mortality rate. Slow-release metformin will work longer in the body with a single dose everyday be an alternative drug for weight loss. The purpose of this study was to compare the effectiveness of slow-release metformin compared to metformin regular to body weight and calorie intake in volunteers with obesity. The study was conducted on 16 volunteers who were divided into two groups in pairs. Volunteers will be measured weight and calorie intake with a 24-hour food recall method, data was taken at the time before the intervention, the end of week 1st, 2nd, 3rd, and 4th. The result obtained weight loss better in the group receiving slow-release metformin by 5.08% compared to the group receiving regular metformin by 2,60%, but there was no significant difference between the groups in terms of calorie intake during the study. The conclusion of this study is a slow-release metformin is greater in weight loss than regular metformin, but does not affect the amount of calorie intake.Keywords: Metformin, slow-release, weight loss, calorie intake, obesity
Acute Toxicity Tests of Basil Leaves (Ocimumsanctum) Ethanolic Extract Determined By LD50 and Renal Histopathology Cholis Abrori; Khana Nurfadhila; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.6501

Abstract

Basil leaves are widely used as herbal remedies and have proven many benefits because the content of phytonutrients includes antioxidants, but at certain doses a compound retains a probability of causing toxicity in the body. This study aims to determine the acute toxicity of ethanolic extract of basil leaves seen from the value of LD50 range and renal histopathology which is the vital organ of the target of toxicity in the body. The method of acute oral toxicity test was OECD 420 fix dose procedure method with a group of 5 Balb/c female mice given a multilevel dosage. The initial dose is 2000 mg/Kg.b.w selected on a sighting study as a dose that may cause mild toxicity symptoms but does not cause death. There are 2 groups consist of treatment with dose at LD50 value and control. The result of this research showed that LD50 value of ethanol extract of Ocimum sanctum > 2000 mg/Kg.b.w. The mean renal histopathologyc scores between the control and the treatment were significantly different by The Mann-Whitney test with significance value of p=0.018. Ocimum sanctum ethanolic extract is classified as non-toxic compounds but there was a change in renal histopathology of mice in the form of focal lesions after acute exposure at highest dose of OECD 420 method. Keywords: acute toxicity test, renal histopathology, basil leaves
Acute Toxicity of Ethanol Leaves Extracts of Cassava (Manihot esculenta) on Liver Histopathology of Wistar Rats Sheillavi Fauziah Alex Saddamiah; Rena Normasari; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 4 No 1 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i1.6741

Abstract

Cassava leaves (Manihot esculenta) contain cyanogenic glylcoside as toxicant. Cyanogenic glycoside can be hydrolized into glucose and cyanohydrin acetone which is then decomposed into cyanide. Cassava leaves are used by the community as a source of food and traditional medicine. However, there is a report of incidents of intoxication and death from cassava consumption in Kenya. This research is intended to know the effect of toxic dose ethanol extract of cassava leaves to liver histopathology of Wistar rats. This study was conducted through two stages, sighting study and main study. Both studies used initial dose level 2000 mg/kg and given once at the first day of each study. Main study consists of two groups, control group given 0,5% Na-CMC and treatment group given ethanol extract of cassava leaves dose 2000 mg/kg. All animals were observed for 14 days. Liver histopathology scores were obtained. Mann Whitney test showed that p= 0,009 (p<0,05) so that can be concluded that ethanol extract of cassava leaves dose 2000 mg/kg can cause histopathological changes in the liver of Wistar rats represented by cloudy swelling degeneration, hydropic degeneration, and necrosis in some cell.
Aedes aegypti Mosquito Potential Larvacidal of Phyllantus niruri L. Leaves Ethanol Extracts Moh. Lutfi Hasbullah; Yudha Nurdian; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 5 No 1 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i1.6775

Abstract

Dengue hemorrhagic fever (DHF) is a disease caused by dengue virus transmitted by Aedes aegyptifemale mosquitoes with four major clinical manifestations, such as high fever, hemorrhage,hepatomegaly, and signs of circulatory failure. Indonesia was reported as the 2nd country with thelargest dengue cases among 30 endemic countries. The larvicidal powder is used as one of thedengue virus vector controllers. This study aims to determine the effect of ethanol extract of smallgooseberry leaves (Phyllantus niruri L.) to the death of Aedes aegypti mosquitoes. This study usedquasi experimental method with post test only controlled group design with 1 positive control group(Temephos), 1 group of negative control (tap water), and 5 treatment groups (0.0625%, 0.125%,0.25% , 0.5% and 1% extract) used 20 larvaes of Aedes aegypti instar III each group. The results of thetreatment group extract with a concentration of 0.5% and 1% obtained 100% dead larvae. The resultof linear regression test showed the effect of meniran leaf extract on the death of larvae Ae. aegyptiwith R2 value of 65.2%. The larvacid activity of ethanol extract leaves meniran against larvae Ae.aegypti instar III was directly proportional to concentration with LC50 of 0.174% with 95% confidenceinterval (0.155-0.195).
The Larvacidal Activity of Ethanol Extracts of Phyllanthus acidus Leaves on The Culex quinquefasciatus Instar III/IV Larvae Afifatun Hasanah; Bagus Hermansyah; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 5 No 2 (2019)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v5i2.6842

Abstract

Culex quinquefasciatus was one of a vector of filariasis disease caused by filarial worm infection. Mode of transmission was through mosquito bites that contain filaria worm. To overcome the problem in terms of eradicating the mosquito larvae was by searching for safe biological materials for humans and the environment, one of them was Phyllanthus acidus leaves. The purposes of this research were to know whether the ethanol extract of Phyllanthus acidus leaves have larvicidal activity on Culex quinquefasciatus instar III / IV larvae and to know the lethal concentration 50 (LC50) ethanol extract of Phyllanthus acidus leaves on Culex quinquefasciatus instar III / IV larvae within 24 hours. This study used true experimental method with post test only controlled group design with 1 positive control group (Temephos), 1 negative control group (Aquades and DMSO), and 5 treatment groups (0.0625%; 0.125%; 0.25%, 0.5% and 1% extract) respectively 20 Culex quinquefasciatus instar III/IV larvae. The result of regression test of inverse to know the effect of leaf extract of ceremai to the death of Culex quinquefasciatus larvae obtained R2=0909 which was mean the effect of ethanol extract of Phyllanthus acidus leaves to the number of the death of Culex quinquefasciatus larvae equal to 90.9%. The result of probit test obtained LC50 result of 0.189% with 95% confidence interval (0.142% -0.233%).
The Effectiveness of Vitamin D Addition to Decreasing Blood Glucose Levels of Hyperglycemic Mice Model with Glimepirid Therapy Tsintani Nur Aristiana; Cholis Abrori; Muhammad Ali Shodikin
Journal of Agromedicine and Medical Sciences Vol 6 No 2 (2020)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v6i2.10206

Abstract

Abstract Low 25-hydrocyvitamin D (25(OH)D3) levels are usually found in patients with type 1 and type 2 diabetes mellitus. This study aims to compare the effectiveness of fasting blood glucose levels in hyperglycemic mice model with glimepirid single therapy, hyperglycemic mice model with vitamin D, and mice model of hyperglycemic with glimepirid therapy plus vitamin D. This study used the true experimental research design with the randomized posttest only control group design. There were 25 male mice (Mus musculus) strain Balb/C with 20-30 g body weight and 2-3 months old which were grouped into 5 groups. The negative control group (K1) was injected with placebo and the positive control group (K2) was injected with STZ 150 mg/kgBW i.p. Groups P1, P2, and P3 were given STZ injection of 150 mg/kgBW i.p and given glimepirid 0.26 mg/kgBW; vitamin D 6,5 ml/kgBW; glimepirid 0,26 mg/kgBW with vitamin D supplementation 6,5 ml/kgBW. The results of the Tukey post hoc tests obtained differences in the mean of delta KGD between groups P1 and K2 = 122,55; in group P2 with K2 = 81,60; and in group P3 with K2 = 74,40. From these data, it can be concluded that in the group given glimepirid plus vitamin D there was no additional effectiveness in decreasing fasting blood glucose levels of hyperglycemic mice model compared to the group given only glimepirid therapy and the group given vitamin D alone. Keywords: diabetes mellitus, vitamin D, glimepiride, streptozotocin.
Analysis of Risk Factors for Obesity in Urban Children in Some Elementary School in Jember Regency Jasmine Fachrunnisa; Cholis Abrori; Dwita Aryadina Rachmawati
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The prevalence of obesity in children has steadily increased, not only in the world but also in Indonesia. Urban area as a central of economic led the higher prevalence of childhood obesity than in rural areas. The objective of this study was to analyze the risk factors associated with obesity among urban elementary school childrens in Jember. A cross sectional study was conducted with a total sample of 176 pupils. Anthropometric status determined using body mass index for age and obesity stated if z-score exceed >+2SD based on WHO 2007. The questionnaire about risk factors was filled with interview. Analysis data performed with univariate, bivarate, and multivariate analysis. This study showed the prevalence of obesity was 17%. Overall, our result showed that in non modifiable risk factors, the prevalence of obesity was significantly higher in children who had obese parent when compared to children who hadn't. Children who had obese parent had the more risk of obesity by 6 times. In modifiable risk factors, children who had meal more than 3 times per day had the more risk of obesity by 2 times. Drinking milk frequently according to Dietary Guideline for American 2015 has a protective factors against obesity.Keywords: childhood obesity, urban, risk factor
The Correlation between HIV/AIDS Positive Pregnant Mother with Infant APGAR Score in RSD dr. Soebandi Jember Nurlaila Ayu Purwaningsih; Muhammad Ali Shodikin; Cholis Abrori
Journal of Agromedicine and Medical Sciences Vol 4 No 3 (2018)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v4i3.6781

Abstract

Human Immunodeficiency Virus (HIV) is a virus that decreased immunity and a set symptoms of diseases called Acquired Immune Deficiency Syndrome (AIDS). One of the major risk factors for HIV transmission is perinatal transmission about 2.8% during pregnancy, delivery, and postpartum. HIV positive mothers have a potential to give birth infants with low APGAR. APGAR Score was used as a reference to determine asphyxia in the first and fifth minutes of life. The purpose of this research were to determine the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score and to determine the other factors that affect the infant APGAR Score in RSD dr. Soebandi Jember. This research used observational analytic survey method with cross sectional design using medical record of HIV positive and negative pregnant women from August 2014-July 2017 in RSD dr. Soebandi Jember as a subject that qualify the inclusion and exclusion criteria. This research used case group sampling technique by total sampling and control group by simple random sampling each 52 samples. Test result of the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score using Chi-Square test obtained p value=1.000 (OR=1.13) that means there was no significant correlation. Test result of the correlation between the other factors that affect infant APGAR Score concluded that there were no significant correlation. Keywords: pregnant mother, HIV/AIDS, APGAR Score, infant
The Effect of Alopurinol on Blood Urea Nitrogen and Creatinine Serum Levels in Patients with Chronic Kidney Disease Miftakhul Huda; Pulong Wijang Pralampita; Dini Agustina; Cholis Abrori; Septa Surya Wahyudi
Journal of Agromedicine and Medical Sciences Vol 7 No 1 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i1.10928

Abstract

Chronic kidney disease (CKD) is a structural and function disorder of renal for > 3 months with implications for individual health. CKD has become a health problem throughout the world and its implementation provides a considerable economic burden on the health system. The decreasing value of GFR (glomerular filtration rate) in CKD can cause uric acid retention so that serum uric acid levels increase (hyperuricemia). Hyperuricemia can occur due to an increase in urinary metabolism (overproduction), a decrease in uric acid expenditure (underexcretion), or a combination of both. The group of antihyperuricemic drugs that have good effectiveness and long-term safety is xanthine oxidase inhibitors. The commonly used xanthine oxidase inhibitor drug is allopurinol. The purpose of this study was to determine whether there was an effect of allopurinol on kidney function in CKD patients. The results of this study are expected to provide input in the treatment of hyperuricemia in CKD patients and reduce the progression of CKD. This study used a retrospective observational analytic design with a cross-sectional approach. The study population was CKD patients from January 2018 to January 2019 at Bina Sehat Hospital Jember. The sampling technique uses purposive sampling. This study uses secondary data obtained from medical records of CKD patients at Bina Sehat Hospital Jember. Secondary data obtained in the form of identity data and the results of laboratory tests of patients. The medical record data that has been obtained is distributed and analyzed using a paired T-test to compare the mean or mean differences of the two groups in pairs. The bivariate test results for blood urea nitrogen and serum creatinine levels in CKD patients were obtained p <0.001. Based on these results there is a significant relationship between blood urea nitrogen and serum creatinine levels before and after consuming allopurinol. The conclusion was that allopurinol was shown to be able to provide an effect on the kidney function of CKD patients based on blood urea nitrogen and serum creatinine levels. Keywords: Chronic kidney disease, hyperuricemia, allopurinol
Risk Factors Analysis of Hypertension Incidence at Karangtengah Public Health Center, Wonogiri Regency Atina Robbiatul Azizah; Angga Mardro Raharjo; Inke Kusumastuti; Cholis Abrori; Pipiet Wulandari
Journal of Agromedicine and Medical Sciences Vol 7 No 3 (2021)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v7i3.23979

Abstract

Hypertension is the most common disease found in Karangtengah Health Center, Wonogiri Regency. The incidence of hypertension can be influenced by factors such as: factor that can not be changed consists of age, gender, family history of illness and modifiable factors consisted of obesity, occupation, and smoking history. Of these risk factors, still unknown factors which increse the incidence of hypertension in Karang Tengah Public Health Center. The purpose of this study was to determine the relationship of these risk factors with the incidence of hypertension and the determinants of the incidence of hypertension in Karangtengah Public Health Center, Wonogiri Regency. This type of research is analytic observational with a cross-sectional design. The sample of this study used the total sampling method, namely all medical record data of new adult patients (>26 years) with a history of chronic diseases who came to Karangtengah Public Health Center, Wonogiri Regency in October 2020 and this study was conducted in March 2021. There were 76 patients. Most of the patients had hypertension (n=42; 55.3%), including the category of elderly (n=55; 72.4%), women (n=41; 53.9%). More patients had a family history of disease (n=50; 65.8%), were obese (n=40; 52.6%), had minimal work activities (n=44; 57.9%), and had a history of smoking (n=42; 55.3%). The risk factors associated with the incidence of hypertension were age, gender, family history of disease, BMI, occupation, and smoking history (all p<0.05). Keywords: Hypertension, age, family history, BMI, occupation
Co-Authors Afifatun Hasanah Angga Mardro Raharjo Atina Robbiatul Azizah Bagus Hermansyah Chikita R Hanifati Deti Rosalina Dimas Zabirrurohman Putra Dini Agustina Dion Krismashogi Dharmawan Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus ENNY SUSWATI Erma Sulistyaningsih Farida Yan Pratiwi Kurnia Fath Arina Fahma Fauqi Amalia Hairrudin Hairrudin Ida Srisurani Wiji Astuti Ika Rahmawati Sutejo Indi Kamilia Fitri Inke Kusumastuti Jasmine Fachrunnisa Justina Evy Tyaswati Khana Nurfadhila Laili, Elisa Fadia Lucky Tiya M. Ali Shodikin M. Ihwan Narwanto Mauliya Sri Sukmawati Wahyudi Miftakhul Huda Moh. Lutfi Hasbullah Muhamad Hasan Muhammad Hasan Mushab Mushab Natasha Amelia Nurlaila Ayu Purwaningsih Nyoman Defriyana Suwandi Olyvia Yulyani Khaerul Putri Pipiet Wulandari Pralampita, Pulong Wijang Prayoga Adinawer Sirait Rena Normasari Rezza Putri Mahartika septa surya wahyudi, septa surya Sheillavi Fauziah Alex Saddamiah Tsintani Nur Aristiana Yedi Murdanu Yudha Nurdian Yunita Armiyanti Zahrah Febianti